Houston Methodist scientists have uncovered an unexpected side of a protein best known for its link to brain diseases. The ...

Outcomes for Children With Type II and Type III Pleuropulmonary Blastoma Following Chemotherapy: A Report From the International PPB/DICER1 Registry We developed and analyzed a functional Low-pass ...

Management of Diffuse Large B-Cell Lymphoma: Are We Getting Smarter? In the article that accompanies this editorial, Chung et al 16 describe a functional assay, Low-pass Genomic Instability ...

Patients with mismatch repair deficient gastric cancer demonstrated better median overall survival when skipping perioperative chemotherapy, according to a preprint study. Median overall survival is ...

Please provide your email address to receive an email when new articles are posted on . Mismatch repair (MMR) screening showed MMR deficiency in one-third of sebaceous carcinoma (SC) cases. Rates of ...

The US Food and Drug Administration has approved a DNA mismatch repair (MMR) companion test to identify patients suitable for treatment with Merck's pembrolizumab (Keytruda). The Ventana MMR RxDx ...

Please provide your email address to receive an email when new articles are posted on . Results showed a DFS benefit with the addition of pembrolizumab to chemotherapy for patients with mismatch ...

Patients with reduced DNA mismatch repair protein expression were more likely to respond to immune checkpoint inhibitors (ICIs), although this study had a small sample size. Patients with cutaneous ...

Praveen Vikas, MD; Hans Messersmith, MPH; Carolyn Compton, MD, PhD; Lynette Sholl, MD; Russell R. Broaddus, MD; Anjee Davis, MPPA; Maria Estevez-Diz, MD, PhD; Rohan ...

DNA is well known as the blueprint of life, necessary for an organism to facilitate living processes. DNA can be damaged by various factors such as radical metabolites, radiation, and some toxic ...